When creating a new manufacturing facility, Hosokawa Micron’s customer sought their advice on the best system options for charging a reactor vessel with bulk powders while ensuring that operators and ...
Powder-container design affects discharge rate, cleanability, and powder flow. Flow problems, such as ratholing, arching, and erratic flow, can be eliminated with appropriate container geometry.
Case studies on the manufacture of a bluk powder and the development of a tablet show the application of QbD principles. The changing development paradigm resulting from FDA’s quality-by-design (QbD) ...